TP53 Mutations in Head and Neck Squamous Cell Carcinoma
نویسندگان
چکیده
منابع مشابه
Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma.
PURPOSE TP53 is a key gene in cellular homeostasis and is frequently mutated in head and neck squamous cell carcinoma (HNSCC). There is a variety of TP53 mutations, each with its own biological and clinical implication. Aim of the study was to assess the prognostic significance of TP53 mutations in HNSCCs and to identify the most relevant mutation. EXPERIMENTAL DESIGN TP53 mutation status was...
متن کاملImaging, Diagnosis, Prognosis Prognostic Significance of Truncating TP53 Mutations in Head and Neck Squamous Cell Carcinoma
Purpose: TP53 is a key gene in cellular homeostasis and is frequently mutated in head and neck squamous cell carcinoma (HNSCC). There is a variety of TP53mutations, each with its own biological and clinical implication. Aim of the study was to assess the prognostic significance of TP53 mutations in HNSCCs and to identify the most relevant mutation. Experimental Design: TP53 mutation status was ...
متن کاملHead and Neck Squamous Cell Carcinoma Mutations in TP53 Prognostic Significance of Truncating
Purpose: TP53 is a key gene in cellular homeostasis and is frequently mutated in head and neck squamous cell carcinoma (HNSCC). There is a variety of TP53mutations, each with its own biological and clinical implication. Aim of the study was to assess the prognostic significance of TP53 mutations in HNSCCs and to identify the most relevant mutation. Experimental Design: TP53 mutation status was ...
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PURPOSE Recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase catalytic alpha (PIK3CA) gene in several human solid tumors. Although gene amplifications of PIK3CA have been reported in head and neck squamous cell carcinoma (HNSCC), small mutation of the gene has not been evaluated in HNSCC previously. In this study, we examined the mutation frequency...
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Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...
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ژورنال
عنوان ژورنال: Otolaryngology–Head and Neck Surgery
سال: 2011
ISSN: 0194-5998,1097-6817
DOI: 10.1177/0194599811415823a165